Essay --

The development of the heart is a complicated process that implicates cell specification and differentiation, including tissue formation, shaping and alteration, to create a functional organ. The zebrafish has become a potential model system to disentangle the fundamental genetic, molecular, and cellular mechanisms of cardiac development and function. The liver is one of the essential organ in mammals. It performs many functions such as help the body digest food, store energy, and remove poisons. The liver also completes many regulatory functions that are critical to fetal development and to life in general. However, failure to perform theses function can result in many mammal liver diseases. Hepatomegaly is a symptom that associate with several liver disorders. Surveys had shown that a large number of the death in the US is caused by chronic liver disease. Liver cancer is another type of liver diseases that is one of the main cause of cancer-related death worldwide. For the past decades, zebrafish has been used as an experimental model to study human liver diseases because of the ability of zebrafish to study vertebrate development. There are many advantages on using zebrafish to study human diseases and using the embryos to grow models of liver diseases. First, there are a lot of benefits such as genetic and embryological-based of zebrafish and the embryonic hematopoiesis does not locate in the liver as it is in mammals. Therefore mutants that has liver size or structure will not have the perplexing phenotype of hematopoietic dysfunction. Second, it takes the zebrafish embryo approximately 3-4 days of development and survives on yolk. After the developmental period, the digestive system of the embryonic fish is fully functional... ...ape formation, movement of cardiac progenitor cells, heart tube, and heart function. A novel development of more specific assays, advance genetic screen efforts will provide new knowledge on cardiac development in the following years. Additionally, because of the zebrafish distinct features and its similarities to vertebrae, the zebrafish might become many researchers preferred model organism to study many mammal organs. Recently, the zebrafish has been used to study mechanisms that cause human cardiac and liver diseases and to model human hereditary and developed cardiac diseases. Due to the increase in sequencing efforts, the developing interest to study human liver and cardiac diseases. Also, the increase of resource and the more availability of the zebrafish model used in clinical and basic researchers involved in studying the liver, as well as cardiac diseases